Non-Coding RNAs in the Cardiac Action Potential and Their Impact on Arrhythmogenic Cardiac Diseases

Cardiac arrhythmias are prevalent among humans across all age ranges, affecting millions of people worldwide. While cardiac vary widely in their clinical presentation, they possess shared complex electrophysiologic properties at cellular level that have not been fully studied. Over the last decade, our current understanding functional roles non-coding RNAs progressively increased. microRNAs represent most studied type small ncRNAs and it has demonstrated miRNAs play essential multiple biological contexts, including normal development diseases. In this review, we provide a comprehensive analysis contribution RNAs, primarily microRNAs, to configuration action potential, as well association distinct types arrhythmogenic